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Endocrine Abstracts

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ea0073oc7.4 | Oral Communications 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Liver GPR55 regulates NAFLD progression from steatosis to fibrosis

Fernández Uxía , Fernández Fondevila Marcos , González Rellán María Jesús , Da Silva Lima Natalia , Buque Xabier , González Rodríguez Marta , Delgado Teresa , Varela Rey Marta V , Eva Novoa , Tojo Marta , Marta Miguel , Diéguez Carlos , Diéguez Miguel , DiéguezMaría Luísa , Arrese Marco , García-Monzón Carmelo , Mato Jose , Aspichueta Jose , Nogueiras Rubén

Background and aimsG protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) is its only known endogenous ligand. Although GPR55 has been linked to energy homeostasis in different organs, its specific role in lipid metabolism in the liver and its contribution to the pathophysiology of non-alcoholic fatty liver disease (NAFLD) remains unknown.MethodWe...
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ea0073aep252 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Inhibition of ATG3 ameliorates liver steatosis by increasing SIRT1 in an autophagic-independent action

Novoa Eva , Nátalia da Silva Lima , Marcos Férnandez Fondevila , Buque Xabier , María Jesús González Rellán , Uxía Fernández Paz , María García Vence , María del Pilar Chantada Vázquez , Bravo Susana , Patricia Marañon , Escudero Adriana , Leiva Magdalena , Fidalgo Miguel , Gomes Pedro , Claret Marc , Sabio Guadalupe , Rey Marta Varela , Delgado Teresa , Miguel López , Carlos Diéguez , María Martínez Chantar , Carmelo García Monzon , Agueda González Rodríguez , Aspichueta Patricia , Rubén Nogueiras Pozo

Background and aimsNonalcoholic fatty liver disease (NAFLD) is a major health threat in both developed and developing countries and is a precursor of the more advanced liver diseases including nonalcoholic steatohepatitis (NASH), liver cirrhosis and liver cancer. One of the numerous molecules participating in the development of liver steatosis is p63. Although p63 is mainly known for its roles as a tumor suppressor and cell maintenance and renewal, we ha...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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